Molecular designs merging circularly polarized luminescence (CPL) and thermally activated delayed fluorescence (CP-TADF) using the concept of chiral perturbation appeared recently as a cornerstone for the development of efficient CP-organic light emitting diodes (CP-OLED). Such devices could strongly increase the energy efficiency and performances of conventional OLED displays,- in which 50% of the emitted light is often lost due to the use of antiglare filters. In this context,- herein,- ten couples of enantiomers derived from novel chiral emitter designs are reported,- exhibiting CPL,- TADF,- and aggregation induced enhancement emission properties (AIEE). Representing the first structure properties relationship investigation for CP-TADF materials,- this thorough experimental and theoretical work brings crucial findings on the key structural and electronic parameters (isomerism,- nature of the carbazole substituents) governing the synergy between CPL and TADF properties. To conclude this study,- the first top emission CP-OLED is elaborated as a new approach of generating CP light in comparison with classical bottom-emission CP-OLED architecture. Indeed,- the top-emission configuration represents the only relevant device architecture for future microdisplay applications. Thereby,- in addition to offer molecular guidelines to combine efficiently TADF and CPL properties,- this study opens new avenues toward practical applications for CP-OLEDs. © 2020 Wiley-VCH GmbH